GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs4665809 | 1 | rs6546728 | chr2:26276531 | HADHA | chr2:26413505-26467594:- | -0.17 | -3.48 | 0.000549 | Gut microbiome composition (summer) |
| THCA | cis | rs4665809 | 1 | rs6546736 | chr2:26293878 | GPR113 | chr2:26531041-26569685:- | 0.45 | 7.1 | 4.54E-12 | Gut microbiome composition (summer) |
| THCA | cis | rs4665809 | 1 | rs6546744 | chr2:26302161 | GPR113 | chr2:26531041-26569685:- | -0.45 | -7.05 | 6.34E-12 | Gut microbiome composition (summer) |
| THCA | cis | rs4665809 | 1 | rs6546766 | chr2:26328680 | GPR113 | chr2:26531041-26569685:- | -0.42 | -6.71 | 5.42E-11 | Gut microbiome composition (summer) |
| THCA | cis | rs4665809 | 1 | rs6546767 | chr2:26328746 | GPR113 | chr2:26531041-26569685:- | -0.42 | -6.71 | 5.42E-11 | Gut microbiome composition (summer) |
| THCA | cis | rs4665809 | 1 | rs6546768 | chr2:26328800 | GPR113 | chr2:26531041-26569685:- | -0.42 | -6.71 | 5.42E-11 | Gut microbiome composition (summer) |
| THCA | cis | rs9309473 | 1 | rs6546835 | chr2:73664715 | ALMS1P | chr2:73872046-73912692:+ | 0.71 | 11.37 | 1.08E-26 | Metabolite levels |
| THCA | cis | rs9309473 | 1 | rs6546835 | chr2:73664715 | NAT8 | chr2:73867850-73869537:- | 0.38 | 6.07 | 2.54E-9 | Metabolite levels |
| THCA | cis | rs9309473 | 1 | rs6546835 | chr2:73664715 | TPRKB | chr2:73956957-73964517:- | -0.17 | -4.3 | 2.12E-5 | Metabolite levels |
| THCA | cis | rs9309473 | 1 | rs6546836 | chr2:73677833 | ALMS1P | chr2:73872046-73912692:+ | 0.73 | 11.71 | 4.93E-28 | Metabolite levels |
| THCA | cis | rs9309473 | 1 | rs6546836 | chr2:73677833 | NAT8 | chr2:73867850-73869537:- | 0.37 | 5.92 | 6.26E-9 | Metabolite levels |
| THCA | cis | rs9309473 | 1 | rs6546836 | chr2:73677833 | TPRKB | chr2:73956957-73964517:- | -0.17 | -4.38 | 1.44E-5 | Metabolite levels |
| THCA | cis | rs9309473 | 1 | rs6546837 | chr2:73677898 | ALMS1P | chr2:73872046-73912692:+ | 0.69 | 11.05 | 2.0E-25 | Metabolite levels |
| THCA | cis | rs9309473 | 1 | rs6546837 | chr2:73677898 | NAT8 | chr2:73867850-73869537:- | 0.37 | 5.86 | 8.81E-9 | Metabolite levels |
| THCA | cis | rs9309473 | 1 | rs6546837 | chr2:73677898 | TPRKB | chr2:73956957-73964517:- | -0.17 | -4.24 | 2.72E-5 | Metabolite levels |